Modulation of NF-кB transcription factor activation by Molluscum contagiosum virus proteins

Modulation of NF-кB transcription factor activation by Molluscum contagiosum virus proteins.

Molluscum contagiosum virus is a human and animal dermatotropic pathogen, which causes a severe disease in immunocompromised individuals. MCV belongs to the Poxviridae family whose members exert immunomodulatory effects on the host antiviral response. Poxviruses interfere with cell signaling pathways that lead to the activation of nuclear factor кB, a pleiotropic transcription factor which is c...

Poxvirus Protein MC132 from Molluscum Contagiosum Virus Inhibits NF-B Activation by Targeting p65 for Degradation.

Molluscum contagiosum virus (MCV) is unique in being the only known extant, human-adapted poxvirus, yet to date, it is very poorly characterized in terms of host-pathogen interactions. MCV causes persistent skin lesions filled with live virus, but these are generally immunologically silent, suggesting the presence of potent inhibitors of human antiviral immunity and inflammation. Fewer than fiv...

Inhibition of interferon gene activation by death-effector domain-containing proteins from the molluscum contagiosum virus.

Apoptosis, NF-κB activation, and IRF3 activation are a triad of intrinsic immune responses that play crucial roles in the pathogenesis of infectious diseases, cancer, and autoimmunity. FLIPs are a family of viral and cellular proteins initially found to inhibit apoptosis and more recently to either up- or down-regulate NF-κB. As such, a broad role for FLIPs in disease regulation is postulated, ...

Molluscum Contagiosum Virus protein MC 005 inhibits NF κ B activation by targeting 1 NEMO - regulated IKK activation

Molluscum Contagiosum

a common bath. Not much work has been done from the point of view of the treatment of the disease and the production of immunity so as to prevent epidemics which may be a serious menace in boarding schools. The disease is said to be self-limiting. Though this may be so it still runs a long course ?at least six months?and within that time there is the danger of infecting several people or of sta...